Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase
Masato Takahashi, Ibuki Hirota, Tomoyuki Nakano, Tomoyuki Kotani, Daisuke Takani, Kana Shiratori, Yura Choi, Masami Haba, Masakiyo Hosokawa
Topics & Concepts
CarboxylesteraseProdrugHydrolysisSteric effectsChemistryMicrosomeAlkoxy groupEster hydrolysisEsteraseMetabolismSubstrate (aquarium)FlurbiprofenMedicinal chemistryStereochemistryAlkylEnzymeOrganic chemistryBiochemistryBiologyEcologyPharmacologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsPharmacogenetics and Drug Metabolism