Insertional activation of <i>STAT3</i> and <i>LCK</i> by HIV-1 proviruses in T cell lymphomas
John W. Mellors, Shuang Guo, Asma Naqvi, Leah D. Brandt, Ling Su, Zhonghe Sun, Kevin W. Joseph, Dimiter Demirov, Elias K. Halvas, Donna Butcher, Beth Scott, Aaron T. Hamilton, Marintha Heil, Baktiar Karim, Xiaolin Wu, Stephen H. Hughes
Abstract
) can play an important role in the development of T cell lymphomas. The development of these cancers appears to be a multistep process involving additional nonviral mutations, which could help explain why T cell lymphomas are rare in persons with HIV-1 infection.
Topics & Concepts
Human immunodeficiency virus (HIV)VirologyT cellCancer researchBiologyMedicineImmunologyImmune systemLymphoma Diagnosis and TreatmentViral-associated cancers and disordersT-cell and Retrovirus Studies