Litcius/Paper detail

Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function

Dong‐Joo Choi, Sanjana Murali, Wookbong Kwon, Junsung Woo, Eun‐Ah Christine Song, Yeunjung Ko, Debosmita Sardar, Brittney Lozzi, Yi-Ting Cheng, Michael R. Williamson, Teng-Wei Huang, Kaitlyn Sanchez, Joanna L. Jankowsky, Benjamin Deneen

2025Nature Neuroscience9 citationsDOIOpen Access PDF

Topics & Concepts

AstrocyteNeuroscienceDiseasePhagocytosisCognitionCognitive declineBiologyPathogenesisTranscription factorNeurodegenerationSOX9HippocampusAlzheimer's diseaseSenile plaquesMicrogliaReceptorFunction (biology)Signal transductionCell biologyMedicineNeuroinflammationNeurogliaAmyloid betaAmyloid (mycology)NeuronAlzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics