Synthesis of C3-sulfone substituted naphthols <i>via</i> rhodium(<scp>iii</scp>)-catalyzed annulation of sulfoxonium ylides with alkynylsulfones
Wucheng Xie, Xinyi Jian, Liyang Zhang, Kexin Jin, Junjun Shi, Feng Zhu
Abstract
C-H activation of sulfoxonium ylides catalyzed by rhodium(iii) with subsequent annulation by alkynylsulfones was accomplished. This methodology offers a step-economical approach for assembling C3-sulfone-substituted naphthols with a high level of regioselectivity that is complementary to previous protocols. The approach has an extensive substrate spectrum and broad functional group tolerance.
Topics & Concepts
AnnulationSulfoneRegioselectivityYlideRhodiumCatalysisChemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCyclopropane Reaction Mechanisms