“On-water” defluorophosphorylation of trifluoromethylated enones with phosphine oxides
Xue‐Qiang Chu, Li-Wen Sun, Cheng Ma, Jiawei Chen, Yulan Chen, Shao‐Fei Ni, Ming-Quan Zhu, Jie Zhou, Mengtao Ma, Zhi‐Liang Shen
Abstract
An efficient “on-water” reaction of β-trifluoromethylated enones with phosphine oxides was developed for the preparation of phosphorylated gem -difluorodienes with excellent Z -selectivity.
Topics & Concepts
PhosphineChemistrySelectivityPhosphine oxideCombinatorial chemistryOrganic chemistryCatalysisFluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisChemical Synthesis and Analysis