Litcius/Paper detail

iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates

Alex Laperle, Samuel Sances, Nur Yucer, Victoria Dardov, Veronica J. Garcia, Ritchie Ho, AnneB Fulton, Michelle R. Jones, Kristina Roxas, Pablo Avalos, Destiny West, Maria G. Bañuelos, Zhan Shu, Ramachandran Murali, Nigel T. Maidment, Jennifer E. Van Eyk, Michele Tagliati, Clive N. Svendsen

2020Nature Medicine126 citationsDOI

Topics & Concepts

Induced pluripotent stem cellBiologyAlpha-synucleinCell biologyDopaminergicParkinson's diseaseDiseaseDopamineGeneMedicineGeneticsInternal medicineEndocrinologyEmbryonic stem cellParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingCRISPR and Genetic Engineering
iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates | Litcius