<i>In Silico</i>and Electrochemical Studies for a ZnO–CuO-Based Immunosensor for Sensitive and Selective Detection of<i>E. coli</i>
Summaiyya Khan, Akrema Akrema, Sahar Qazi, Rafiq Ahmad, Khalid Raza, Rahis Uddin
Abstract
LPS and the anti-LPS antibody using molecular docking studies. Atomic charge computation and interaction analyses were performed to support our hypothesis. Our results discern that there is a strong correlation between molecular docking studies and electrochemical characterization. The interaction analysis further displays the strong affinity between the antibody-LPS complex when immobilized with a nanoparticle composite (ZnO-CuO).
Topics & Concepts
Escherichia coliBiosensorDetection limitRaman spectroscopyElectrochemistryChemistryNuclear chemistryMaterials scienceNanotechnologyChromatographyElectrodeBiochemistryPhysical chemistryGeneOpticsPhysicsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionElectrochemical Analysis and Applications