Rapid and sensitive multiplex detection of COVID-19 antigens and antibody using electrochemical immunosensor-/aptasensor-enabled biochips
Fuze Jiang, Zhen Xiao, Ting Wang, Jiajia Wang, Jiajia Wang, Lihua Bie, Lanja Saleh, Kathrin Frey, Lianjun Zhang, Jing Wang, Jing Wang
Abstract
We report protein- and aptamer-based electrochemical biochips for low-cost, one-step, sensitive and accurate multiplex detection of SARS-CoV-2 spike (S) and nucleocapsid (N) proteins, and IgG antibody in unprocessed clinical samples, allowing citizens to achieve rapid diagnosis at home or in community settings.
Topics & Concepts
BiochipMultiplexAptamerSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)AntibodyAntigenChemistryChromatographyMolecular biologyVirologyNanotechnologyMaterials scienceMedicineBiologyImmunologyBioinformaticsInfectious disease (medical specialty)DiseasePathologyAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionSARS-CoV-2 detection and testing