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Bortezomib elevates intracellular free Fe2+ by enhancing NCOA4-mediated ferritinophagy and synergizes with RSL-3 to inhibit multiple myeloma cells

Yanyan Zhang, Fen He, Wei Hu, Jingqi Sun, Hongyan Zhao, Yuzhi Cheng, Zhanyou Tang, Jiarui He, Xiangyuan Wang, Tairan Liu, Cong Luo, Zhongwei Lu, Mei Xiang, Yiting Liao, Yihao Wang, Junjun Li, Jiliang Xia

2024Annals of Hematology15 citationsDOI

Topics & Concepts

BortezomibIntracellularAutophagyInducerCell cultureBiologyCancer cellProteasome inhibitorCell biologyProgrammed cell deathFerritinCancer researchApoptosisBiochemistryMultiple myelomaImmunologyProteasomeCancerGeneGeneticsFerroptosis and cancer prognosisIron Metabolism and DisordersDrug Transport and Resistance Mechanisms
Bortezomib elevates intracellular free Fe2+ by enhancing NCOA4-mediated ferritinophagy and synergizes with RSL-3 to inhibit multiple myeloma cells | Litcius