Predicting budesonide performance in healthy subjects and patients with Crohn's disease using biorelevant in vitro dissolution testing and PBPK modeling
Angela Effinger, Caitríona M. O’Driscoll, Mark McAllister, Nikoletta Fotaki
Topics & Concepts
Physiologically based pharmacokinetic modellingBudesonideBioavailabilityPharmacokineticsPharmacologyDrugPopulationChemistryCYP3A4MedicineInternal medicineCorticosteroidCytochrome P450MetabolismEnvironmental healthInflammatory Bowel DiseaseHelicobacter pylori-related gastroenterology studiesBiosimilars and Bioanalytical Methods