Biogenic Amines Increase the Odds of Bacterial Vaginosis and Affect the Growth of and Lactic Acid Production by Vaginal <i>Lactobacillus</i> spp.
Joanna-Lynn C. Borgogna, Michelle Shardell, Savannah G. Grace, Elisa K. Santori, Benjamin Americus, Zhong Li, Alexander Ulanov, Larry J. Forney, Tiffanie M. Nelson, Rebecca M. Brotman, Jacques Ravel, Carl J. Yeoman
Abstract
Lactobacillus spp. are credited with providing the primary defense against gynecological conditions, including BV, most notably through the acidification of the vaginal microenvironment, which results from their production of lactic acid. The microbial production of BAs has been hypothesized to play a mechanistic role in diminishing Lactobacillus species-mediated protection, enabling the colonization and outgrowth of diverse anaerobic bacterial species associated with BV.
Topics & Concepts
Bacterial vaginosisLactobacillusLactic acidLactobacillaceaeBiologyMicrobiologyColonizationBacteriaFood scienceFermentationGeneticsReproductive tract infections researchGut microbiota and healthUrinary Tract Infections Management