Mitochondrial SIRT3 Deficiency Results in Neuronal Network Hyperexcitability, Accelerates Age-Related Aβ Pathology, and Renders Neurons Vulnerable to Aβ Toxicity
Isabella Perone, Nathaniel Ghena, Jing Wang, Chelsea D. Mackey, Ruiqian Wan, Sulochan Malla, Myriam Gorospe, Aiwu Cheng, Mark P. Mattson
Topics & Concepts
SIRT3ExcitotoxicitySirtuinKainic acidMitochondrionBiologyNeuroscienceGenetically modified mouseInternal medicineEndocrinologyCell biologyTransgeneMedicineAcetylationGlutamate receptorBiochemistryReceptorGeneSirtuins and Resveratrol in MedicineBiochemical effects in animalsAlzheimer's disease research and treatments