Orally Administered Bifidobacterium adolescentis Diminishes Serum Glutamate Concentration in Mice
Félix Royo, Hector Tamés, Guillermo Bordanaba-Florit, Diana Cabrera, Maria Azparren‐Angulo, Clara Garcia‐Vallicrosa, Abelardo Margollés, Lorena Ruíz, Patricia Ruas‐Madiedo, Juan Manuel Falcón‐Pérez
Abstract
This work presents the results of a trial using mice as a model that were fed with a bacterial strain of the species B. adolescentis, which possesses different active genes capable of degrading glutamate and converting it into GABA. Indeed, the bacterium is able to survive the passage through the gastric tract and, more importantly, the animals reduce over time the concentration of glutamate in their blood. The importance of this result lies in the fact that several chronic ailments, such as fibromyalgia, are characterized by an increase in glutamate. Our results indicate that an oral diet with this probiotic-type bacteria could reduce the concentration of glutamate and, therefore, reduce the symptoms associated with the excess of this neurotransmitter.