Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells
Shohei Uchinomiya, Naoya Matsunaga, Koichiro Kamoda, Ryosuke Kawagoe, Akito Tsuruta, Shigehiro Ohdo, Akio Ojida
Abstract
Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, we report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.
Topics & Concepts
FluorescenceBeta oxidationChemistryFatty acidEnzymeBiochemistryMetabolic activityMetabolic pathwayLiving cellBETA (programming language)BiologyCell biologyProgramming languageQuantum mechanicsComputer scienceBiological systemPhysicsPeroxisome Proliferator-Activated ReceptorsMetabolomics and Mass Spectrometry StudiesMolecular Sensors and Ion Detection