Sequential C–S and S–N Coupling Approach to Sulfonamides
Kai Chen, Wei Chen, Wei Chen, Bing Han, Wanzhi Chen, Wanzhi Chen, Miaochang Liu, Huayue Wu
Abstract
A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts.
Topics & Concepts
ChemistryCatalysisCombinatorial chemistryCoupling (piping)SulfonamidePotassiumMetalCoupling reactionComponent (thermodynamics)Organic chemistryMedicinal chemistryEngineeringPhysicsThermodynamicsMechanical engineeringSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions