Cyclopropane Fatty Acids Are Important for <i>Salmonella enterica</i> Serovar Typhimurium Virulence
Joyce E. Karlinsey, Angela M. Fung, Norah Johnston, Howard Goldfine, Stephen J. Libby, Ferric C. Fang
Abstract
A variety of eubacteria, plants, and protozoa can modify membrane lipids by cyclopropanation, which is reported to modulate membrane permeability and fluidity. The ability to cyclopropanate membrane lipids has been associated with resistance to oxidative stress in Mycobacterium tuberculosis , organic solvent stress in Escherichia coli , and acid stress in E. coli and Salmonella .
Topics & Concepts
VirulenceBiologyBiochemistrySalmonella entericaMutantMicrobiologyEscherichia coliNADPH oxidaseEnterobacteriaceaeBacterial outer membraneMembrane lipidsEnzymeBacteriaSalmonellaFatty acidLipid AOxidase testATP synthaseOxidative stressLipid Membrane Structure and BehaviorSalmonella and Campylobacter epidemiologyBacterial Genetics and Biotechnology