Disruption in <i>ACTL7A</i> causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest
Aijie Xin, Ronggui Qu, Guowu Chen, Ling Zhang, Junling Chen, Chengqiu Tao, Jing Fu, Jianan Tang, Yanfei Ru, Ying Chen, Xiandong Peng, Huijuan Shi, Feng Zhang, Xiaoxi Sun
Abstract
ACTL7A deficiency is a novel male factor inducing early embryonic arrest that can be overcome by artificial oocyte activation.
Topics & Concepts
UltrastructureSpermEmbryonic stem cellCell biologyBiologyAndrologyEmbryoEmbryogenesisAnatomyMedicineGeneticsGeneReproductive Biology and FertilityAnimal Genetics and ReproductionSperm and Testicular Function