Enterovirus A71 Vaccines
Mei-Ling Li, Shin‐Ru Shih, Blanton S. Tolbert, Gary Brewer
Abstract
Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus infection. There are currently three inactivated, whole EV-A71 vaccines licensed by the China NMPA (National Medical Products Administration). Several other types of vaccines, such as virus-like particles and recombinant VP1 (capsid protein), are also under development. In this review, we discuss recent advances in the development of EV-A71 vaccines.
Topics & Concepts
VirologyFoot-and-mouth diseaseEnterovirus 71VaccinationCapsidVirusEnterovirusMedicineEnterovirus InfectionsHand-foot-and-mouth diseaseDiseasePathologyViral Infections and Immunology ResearchViral gastroenteritis research and epidemiologyAnimal Disease Management and Epidemiology