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Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers

Fatma G. Abdulrahman, Hamada S. Abulkhair, Hoda S. El Saeed, Nehad M. El‐Dydamony, Ebtehal M. Husseiny

2024Bioorganic Chemistry25 citationsDOI

Topics & Concepts

ChemistryApoptosisCytotoxic T cellCaspaseCytotoxicityIC50Docking (animal)Mechanism of actionCell cultureLead compoundEpidermal growth factor receptorCell cycleIn silicoCancer researchIn vitroBiochemistryStereochemistryProgrammed cell deathReceptorBiologyNursingGeneticsMedicineGeneSynthesis and biological activitySynthesis of heterocyclic compoundsSynthesis and Characterization of Heterocyclic Compounds
Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers | Litcius