Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI
Ni Yin, Bangchuan Hu, Guohua Wu, Ziqiang Shao, Yang Zheng, Run Zhang, Jun Jin, Jun Hong, Xianghong Yang, Ren-Hua Sun, Jinquan Liu, Shi‐Jing Mo
Abstract
Our preclinical data propose that interrupting NETs formation in combination with Fn14 mAb might be a feasible therapeutic strategy for septic AKI.
Topics & Concepts
Neutrophil extracellular trapsSepsisAcute kidney injuryChromatin immunoprecipitationCancer researchImmunologyBiologyMedicineInflammationGene expressionInternal medicineGeneBiochemistryPromoterNeutrophil, Myeloperoxidase and Oxidative MechanismsS100 Proteins and AnnexinsSepsis Diagnosis and Treatment