Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
Taehyung Kim, Ha Na Hyun, Roun Heo, Keonwook Nam, Kyungjik Yang, Young Min Kim, Lawrence Yoon Suk Lee, Jae Yoon An, Jae Hyung Park, Ki Young Choi, Young Hoon Roh
Abstract
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
Topics & Concepts
CytotoxicitySmall interfering RNACancer cellIntracellularDual (grammatical number)ChemistryApoptosisNanoparticleDual roleGene deliveryRNA interferenceCell biologyCancerRNANanotechnologyCancer researchGeneTransfectionBiochemistryMaterials scienceBiologyCombinatorial chemistryIn vitroGeneticsLiteratureArtRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesMicroRNA in disease regulation