Cutibacterium acnes Induces the Expression of Immunosuppressive Genes in Macrophages and is Associated with an Increase of Regulatory T-Cells in Prostate Cancer
Sabina Davidsson, Jessica Carlsson, Larry Greenberg, Jonny Wijkander, Bo Söderquist, Ann Erlandsson
Abstract
In an immune suppressive tumor microenvironment constituted by immunosuppressive cells and immunosuppressive mediators, tumors may improve their ability to give rise to a clinically relevant cancer. In the present study, we found that C. acnes might contribute to an immunosuppressive environment by recruiting regulatory T cells and by increasing the expression of immunosuppressive mediators such as PD-L1, CCL17, and CCL 18.
Topics & Concepts
Prostate cancerCancerGeneProstateBiologyCancer researchExpression (computer science)Gene expressionImmunologyGeneticsProgramming languageComputer scienceImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction