Structure-activity relationship study of RSL3-based GPX4 degraders and its potential noncovalent optimization
Cangxin Zheng, Chao Wang, Dan Sun, Han Wang, Bingru Li, Guoquan Liu, Zhenming Liu, Liangren Zhang, Ping Xu
Topics & Concepts
ChemistryGPX4Ligand (biochemistry)BiochemistryProteasomeGlutathioneEnzymeGlutathione peroxidaseReceptorProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways