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Advancing sustainable peptide synthesis: methanesulfonic acid–formic acid as a greener substitute for TFA in final global deprotection

Fathima Fidha, Ashish Kumar, Maria Leko, Oleg Marder, S. V. Burov, Anamika Sharma, Beatriz G. de la Torre, Fernando Alberício

2025Green Chemistry5 citationsDOIOpen Access PDF

Abstract

2% Methanesulfonic acid (MSA)–formic acid (FA) as a greener substitute for TFA in final global deprotection.

Topics & Concepts

Methanesulfonic acidChemistryOrganic chemistryPeptideDepolymerizationAmino acidCombinatorial chemistryPeptide synthesisBiorefineryBifunctionalChemical Synthesis and Reactions
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