Clinical Performance of Plasma Metagenomic Sequencing in Immunocompromised Pediatric Patients
Alice Lehman, Lea R. Goren, Michael D. Evans, Olivia Toles, Daniel Drozdov, Shannon Andrews, Shane C. McAllister, Beth K Thielen
Abstract
The performance of plasma metagenomic next-generation sequencing was evaluated in an immunocompromised pediatric population. The clinical impact was limited, with management changes in 13% of cases. Moreover, organisms thought to be non-pathogenic were commonly detected. Prospective studies in specific populations are required to clarify the utility of this emerging technology.
Topics & Concepts
MetagenomicsMedicineDNA sequencingComputational biologyIntensive care medicineBioinformaticsBiologyGeneticsGeneMycobacterium research and diagnosisInfections and bacterial resistanceAntibiotic Resistance in Bacteria