Protein-avoidant ionic liquid (PAIL)–coated nanoparticles to increase bloodstream circulation and drive biodistribution
Christine M. Hamadani, Morgan J. Goetz, Samir Mitragotri, Eden E. L. Tanner
Abstract
-glycolic acid) (PLGA) NPs. Compared with bare PLGA and poly(ethylene glycol)-coated PLGA particles, the PAIL-PLGA NPs showed resistance to protein adsorption in vitro and greater retention in blood of mice at 24 hours. Choline hexenoate redirected biodistribution of NPs, with preferential accumulation in the lungs with 50% of the administered dose accumulating in the lungs and <5% in the liver. Lung accumulation was attributed to spontaneous attachment of the PAIL-coated NPs on red blood cells in vivo. Overall, ionic liquids are a promising class of materials for NP modification for biomedical applications.
Topics & Concepts
BiodistributionIonic liquidNanoparticleSystemic circulationBlood circulationCirculation (fluid dynamics)Materials scienceChemistryBiophysicsChemical engineeringNanotechnologyInternal medicineMedicineBiochemistryBiologyPhysicsCatalysisIn vitroTraditional medicineThermodynamicsEngineeringIonic liquids properties and applicationsQuantum Dots Synthesis And PropertiesAdvanced Nanomaterials in Catalysis