Editorial: Trained Immunity-Based Vaccines

Abstract

Trained immunity is defined as a type of memory of the innate immune system by which innate immune cells undergo a long-term adaptation, largely dependent on persistent epigenetic modifications and metabolic reprogramming of these cells (1). Myeloid cells can be trained with a variety of stimuli (typically of microbial origin) that improve their responsiveness to second stimuli (same or unrelated) in a fairly stable manner. The mechanistic basis of trained immunity and the diversity of trained cells behaviors may have important implications not only for innate but also for adaptive immunity and, therefore, for a response to vaccines or for their design (2).

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