Implications of non-native metal substitution in carbonic anhydrase – engineered enzymes and models
Dyuti Bhandary, Sam P. de Visser, Gourab Mukherjee
Abstract
The effect of non-native metal ions on the carbonic anhydrase activity of CO 2 hydration has been studied by substituting the native zinc with non-native metal ions in engineered enzymes and biomimetic models.
Topics & Concepts
Carbonic anhydraseEnzymeZincChemistryMetalBiochemistrySubstitution (logic)Combinatorial chemistryOrganic chemistryComputer scienceProgramming languageEnzyme function and inhibitionEnzyme Catalysis and ImmobilizationPolyamine Metabolism and Applications