Molecular Mechanisms to Target Cellular Senescence in Aging and Disease
Serena Marcozzi, Antonio Paolo Beltrami, Marco Malavolta
Abstract
Cellular senescence is a state of irreversible cell cycle arrest in response to several stressors, including DNA damage, increased cellular oxidative stress, telomere shortening, oncogene activation, and a deep epigenetic remodeling [...].
Topics & Concepts
TelomereCellular AgingSenescenceCellular senescenceEpigeneticsCell biologyDNA damageBiologyCell cycleOxidative stressCellDNAGeneticsPhenotypeGeneBiochemistryTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatonin