Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation
Émilie Viennois, Alexis Bretin, Philip E. Dubé, Alexander C. Maue, Charlène Dauriat, Nicolas Barnich, Andrew T. Gewirtz, Benoît Chassaing
Abstract
mice, AIEC mono-colonization results in severe intestinal inflammation in response to emulsifiers. Exposure of AIEC to emulsifiers in vitro increases its motility and ability to adhere to intestinal epithelial cells. Transcriptomic analysis reveals that emulsifiers directly induce expression of clusters of genes that mediate AIEC virulence and promotion of inflammation. To conclude, emulsifiers promote virulence and encroachment of pathobionts, providing a means by which these compounds may drive inflammation in hosts carrying such bacteria.
Topics & Concepts
InflammationGene expressionGeneBiologyMedicineImmunologyGeneticsGut microbiota and healthProbiotics and Fermented FoodsDigestive system and related health