BopN is a Gatekeeper of the <i>Bordetella</i> Type III Secretion System
Kevin Munoz Navarrete, Ladislav Bumba, Tatyana Prudniková, Ivana Malcová, Tania Romero Allsop, Peter Šebo, Jana Kamanová
Abstract
The T3SS is utilized by many Gram-negative bacteria to deliver effector proteins from bacterial cytosol directly into infected host cell cytoplasm in a regulated and targeted manner. Pathogenic bordetellae use the T3SS to inject the BteA and BopN proteins into infected cells and upregulate the production of the anti-inflammatory cytokine interleukin-10 (IL-10) to evade host immunity.
Topics & Concepts
SecretionType three secretion systemEffectorBiologyBordetella pertussisMicrobiologyBordetella bronchisepticaBordetellaVirulenceTransloconCytoplasmCell biologyBacteriaChromosomal translocationGeneBiochemistryGeneticsBacterial Infections and VaccinesEscherichia coli research studiesRNA and protein synthesis mechanisms