Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes
Y. Gao, Lijuan Gao, Endiao Zhu, Yunhong Yang, Jie Mi, Jiaqian Zhang, Zhiqiang Pan, Chengfeng Xia
Abstract
Abstract Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C( sp 3 )−C( sp 3 ) bond and one C( sp 3 )−C( sp 2 ) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds.