Dopamine-triggered one-step functionalization of hollow silica nanospheres for simultaneous lubrication and drug release
Qiangbing Wei, Tian Fu, Lele Lei, Huan Liu, Yixin Zhang, Shuanhong Ma, Feng Zhou
Abstract
Abstract Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both joint lubrication and drug intervention may provide a promising nonsurgical strategy for treatment of OA. Developing novel and simple approaches to fabricate superlubricating nanoparticles with drug release property is highly required. Herein, dopamine triggered one-step polymerization method was employed to fabricate polydopamine/poly(3-sulfopropyl methacrylate potassium salt) (PDA—PSPMA) conjugate coating on hollow silica (h-SiO 2 ) nanosphere surfaces to engineer functional nanoparticles (h-SiO 2 /PDA—PSPMA). The as-prepared h-SiO 2 /PDA—PSPMA exhibits excellent aqueous lubrication performance on biomaterial substrates as well as natural bovine articular cartilage based on hydration effect of negatively charged PDA—PSPMA coating and “rolling” effect of h-SiO 2 nanospheres. In vitro drug loading-release experiments demonstrate that PDA—PSPMA coating functionalized h-SiO 2 nanospheres show high drug-loading and sustained-release capability of an anti-inflammatory drug, diclofenac sodium (DS). Such h-SiO 2 /PDA—PSPMA nanospheres can be potentially used as a synergistic therapy agent for OA treatment combining by simultaneous joint lubrication and drug release.