Classical thiazole orange and its regioisomer as fluorogenic probes for nucleolar RNA imaging in living cells
Mengmeng He, Yusuke Sato, Seiichi Nishizawa
Abstract
= 1200), having superior selectivity for RNA in both solution and living cells. The comparison with TO derivatives carrying different substituents at N1 of the quinoline ring reveals that the slight change in the TO framework significantly affects RNA selectivity, photostability and membrane permeability.
Topics & Concepts
RNAChemistryDNASelectivityNucleic acidBenzothiazoleQuinolineBiophysicsSmall moleculeStereochemistryBiochemistryGeneBiologyOrganic chemistryCatalysisDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanisms