EtOH-mediated cascade C(sp<sup>3</sup>)–H alkylation <i>via</i> aromatization-driven [1,6]-hydride transfer: green and divergent synthesis of spirocyclic azepino[4,3,2-<i>cd</i>]indoles
Yao‐Bin Shen, Qian-Hao Zhuang, Xiao-Lin Wang, Xiao‐De An, Bin Qiu, Tiesheng Shi, Jian Xiao
Abstract
Unprecedented EtOH-mediated cascade C(sp 3 )–H alkylation reactions of 4-dialkylamino-indole-3-carbaldehydes have been realized for the green and divergent synthesis of spirocyclic azepino[4,3,2- cd ]indole derivatives.
Topics & Concepts
AromatizationChemistryAlkylationHydrideCascadeCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisHydrogenChromatographyCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsAsymmetric Hydrogenation and Catalysis