Reflex Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of the SpeeDx ResistancePlus GC Assay
Darren Y. J. Lee, Melinda M. Ashcroft, Eric P. F. Chow, Michelle Sait, Vesna De Petra, Marlene Tschaepe, Sigrid Lange, George Taiaroa, Catriona S. Bradshaw, David M. Whiley, Christopher K. Fairley, Benjamin P. Howden, Marcus Y. Chen, Shivani Pasricha, Deborah A. Williamson
Abstract
Resistance-guided therapy (RGT) for gonorrhoea may reduce unnecessary use of broad-spectrum antibiotics. When reflexed from the Aptima Combo 2 assay, the ResistancePlus GC assay demonstrated 94.8% sensitivity and 100.0% specificity for Neisseria gonorrhoeae detection.
Topics & Concepts
Neisseria gonorrhoeaeGonorrheaCiprofloxacinMicrobiologyNeisseriaNeisseriaceaeAntibiotic resistanceBiologyAntibioticsMedicineVirologyBacteriaGeneticsHuman immunodeficiency virus (HIV)Reproductive tract infections researchBacterial Infections and VaccinesStreptococcal Infections and Treatments