Electrochemical assembly of isoxazoles <i>via</i> a four-component domino reaction
Yuanyuan Zhao, Xinyue Li, Simon L. Homölle, Bin Wang, Lutz Ackermann
Abstract
a [1 + 2 + 1 + 1] four-component domino reaction was accomplished in a user-friendly undivided cell setup to assemble valuable five-membered isoxazole motifs. Our approach is characterized by a high level functional group tolerance and operational simplicity, avoiding the tedious and time-consuming preparation of pre-functionalized substrates. Detailed mechanistic studies were conducted including isotopic labeling, kinetic studies, cyclic voltammetry (CV) analysis, and intermediate characterization, providing support for a radical pathway.
Topics & Concepts
DominoElectrochemistryDomino effectCombinatorial chemistryChemistryCascade reactionOrganic chemistryElectrodePhysicsCatalysisPhysical chemistryNuclear physicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions