Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement
Fanny Lassalle, Nicolas Duployez, Flavien Vincent, Antoine Rauch, Tom Denimal, Mickaël Rosa, Julien Labreuche, David Dombrowicz, Bart Staels, Claude Preudhomme, Sophie Susen, Eric Van Belle, Annabelle Dupont
Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) is considered as being a novel age-related risk factor for cardiovascular diseases. By capture-sequencing of a 67-gene panel, we established a large spectrum of CHIP in 258 patients with aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) and assessed their association with long-term survival after TAVR. One or several CHIP variants in 35 genes were identified in 68% of the cohort, DNMT3A and TET2 being the 2 most frequently mutated genes. Patients carrying a TET2-CHIP-driver variant with low variant allele frequency (2%-10%) had a significant decrease in overall survival 5 years after TAVR.