Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA
Natalie Wolff, Sebastian Kollenda, Kai Klein, Κateryna Loza, Marc Heggen, Leonie Brochhagen, Oliver Witzke, Adalbert Krawczyk, Ingrid Hilger, Matthias Epple
Abstract
. This highlights the strong potential of siRNA-functionalized ultrasmall gold nanoparticles in a broad spectrum of applications, including gene silencing and treatment of viral infections, combined with a minimal dose of gold.
Topics & Concepts
Gene silencingSmall interfering RNAConjugated systemHeLaHerpes simplex virusChemistryBiophysicsNanoparticleColloidal goldMaterials scienceTransfectionIn vitroVirusVirologyBiologyNanotechnologyBiochemistryOrganic chemistryGenePolymerRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesImmunotherapy and Immune Responses