Three‐Component Difunctionalization of Alkenes or Cyclopropanes Using 4‐Cyanopyridine as Pyridylation Reagents

Abstract

Abstract Pyridine cores are important heterocycles that exist in natural products, pharmaceuticals, and chiral ligands. Recently, radical‐based 4‐cyanopyridine has an effective approach for the synthesis of complex pyridines. In this review, we provide an overview of the recent development of multicomponent reactions using 4‐cyanopyridine as pyridylation reagent for rapidly constructing complex molecules, including pyridine core. We systematically classified the recent literatures in the field based on bonding type, including C─C or C‐heteroatom. This review aims to highlight the results of 4‐cyanopyridine as a powerful pyridylation reagent for multicomponent reactions.

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