Aging and metabolism in HFpEF: Pathophysiology and therapeutic implications
Min Ye, Shenghui Feng, Zixuan Xu, Wenfeng He, Chen Liu, Wengen Zhu
Topics & Concepts
Heart failureMedicineReactive oxygen speciesSirtuinBeta oxidationGlycolysisBioenergeticsMitochondrionOxidative stressSirtuin 1mTORC1Oxidative phosphorylationHeart failure with preserved ejection fractionMitophagyMitochondrial ROSEndocrinologyPathophysiologyCell biologyInternal medicineCardiomyopathyPyruvate dehydrogenase complexPathogenesisExercise intoleranceAutophagyDiastolePharmacologyPeroxynitriteBioinformaticsBiologyFlux (metallurgy)LipotoxicitySOD2MetabolismCatabolismAfterloadPhenotypeCardioprotectionDiseaseProteostasisCardiovascular Function and Risk FactorsCardiac Fibrosis and RemodelingHeart Failure Treatment and Management