Polymer chain editing: functionality “knock-in”, “knock-out” and replacement <i>via</i> cross metathesis reaction and thiol-Michael addition
Jie Ren, Junpo He
Abstract
Inspired by the gene editing process, chain editing of synthetic polymers, including functionality “knock-out”, “knock-in” and replacement, was performed through cross metathesis and thiol-Michael addition.
Topics & Concepts
Michael reactionMetathesisGene knockinThiolSalt metathesis reactionPolymerChain (unit)ChemistryOrganic chemistryCatalysisGenePhysicsBiochemistryPolymerizationAstronomyCRISPR and Genetic EngineeringClick Chemistry and ApplicationsRNA Interference and Gene Delivery