Iodine-Mediated Multicomponent Cascade Cyclization and Sulfenylation/Selenation: Synthesis of Imidazo[2,1-<i>a</i>]isoquinoline Derivatives
Li‐Sheng Wang, You Zhou, Shuang‐Gui Lei, Xiaoxiao Yu, Chun Huang, Yan‐Dong Wu, An‐Xin Wu
Abstract
A novel multicomponent cascade cyclization and sulfenylation/selenation using aryl methyl ketones, isoquinolin-1-amine, and sodium arylsulfinates/1,2-diphenyldiselane to synthesize imidazo[2,1-a]isoquinoline derivatives in one-pot via the construction of two C–N bonds and one C–S/C–Se bond has been reported. This multicomponent reaction realizes simultaneous C(sp3)–H amination and sulfenylation/selenation, avoiding complicated prior substrate preparation. This process has simple operating conditions and good substrate compatibility.
Topics & Concepts
IsoquinolineChemistryAminationCascadeArylIodineCombinatorial chemistryAmine gas treatingCascade reactionSubstrate (aquarium)Medicinal chemistryOrganic chemistryStereochemistryCatalysisOceanographyGeologyAlkylChromatographySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions