Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRASG12C inhibitors
Xuanzheng Xiao, Mengzhen Lai, Zilan Song, Meiyu Geng, Jian Ding, Hua Xie, Ao Zhang
Topics & Concepts
ChemistryBicyclic moleculeMoietyKRASKinaseProtein Data Bank (RCSB PDB)StereochemistryDocking (animal)MAPK/ERK pathwayPharmacologyCombinatorial chemistryBiochemistryMutationMedicineGeneNursingProtein Kinase Regulation and GTPase SignalingMelanoma and MAPK PathwaysProtein Tyrosine Phosphatases