Excessive proteostasis contributes to pathology in fragile X syndrome
Susana R. Louros, Sang Soo Seo, Beatriz Maio, Cristina Martinez‐Gonzalez, Miguel A. Gonzalez‐Lozano, Melania Muscas, Nick C. Verity, Jimi Wills, Ka Wan Li, Matthew F. Nolan, Emily K. Osterweil
Abstract
neurons as a contributor to multiple phenotypes that can be targeted for therapeutic intervention.
Topics & Concepts
ProteostasisProteasomeFragile X syndromeFMR1HyperactivationHippocampal formationProtein degradationNeuroscienceBortezomibBiologyUbiquitinCell biologyMedicineInternal medicineGeneticsAlleleGeneMultiple myelomaGenetics and Neurodevelopmental DisordersUbiquitin and proteasome pathwaysAutism Spectrum Disorder Research