Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease
Yichun Shi, Heng Zhang, Qing Song, Guangjun Yu, Zhuoling Liu, Feng Zhong, Zhenghuai Tan, Xiuxiu Liu, Yong Deng
Topics & Concepts
ChemistryIC50AcetylcholinesteraseAntioxidantIn vivoTroloxOxidative stressStereochemistryCholinergicPharmacologyIn vitroBiochemistryAntioxidant capacityNeuroscienceEnzymeBiologyMedicineBiotechnologyCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsComputational Drug Discovery Methods