Synthesis of amantadine clubbed <i>N</i>-aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies
Fatima Tuz Zahra, Aamer Saeed, Atteeque Ahmed, Hammad Ismail, Muhammad Umar Ijaz, Fernando Alberício
Abstract
= 1.334 μM. Molecular docking studies disclosed the binding mechanism and affinity of these new inhibitors within the binding sites of various amino acids. To investigate the association between molecular structural characteristics and inhibitory actions of synthesized derivatives, preliminary structure-activity relationship (SAR) studies were performed. These findings indicated that compounds 6a, 6c, 6d and 6e are potential candidates for hit-to-lead follow-up in the drug-discovery process for treating diabetes and hyperglycemia.
Topics & Concepts
Docking (animal)ChemistryAmantadineArylAmylaseStereochemistryEnzymeUreaseCombinatorial chemistryBiochemistryPharmacologyOrganic chemistryBiologyMedicineNursingAlkylSynthesis and biological activityClick Chemistry and ApplicationsMulticomponent Synthesis of Heterocycles