A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
Grégory Lazarian, Shanye Yin, Elisa ten Hacken, Tomasz Sewastianik, Mohamed Uduman, Alba Font‐Tello, Satyen Gohil, Shuqiang Li, Ekaterina Kim, Heather Joyal, Leah Billington, Elizabeth Witten, Mei Zheng, Teddy Huang, Mariano Severgnini, Valérie Lefebvre, Laura Z. Rassenti, Catherine Gutierrez, Katia Georgopoulos, Christopher J. Ott, Lili Wang, Thomas J. Kipps, Jan A. Burger, Kenneth J. Livak, Donna Neuberg, Fanny Baran‐Marszak, Florence Cymbalista, Ruben D. Carrasco, Catherine J. Wu
Topics & Concepts
BiologyTranscription factorbreakpoint cluster regionCancer researchGeneticsChronic lymphocytic leukemiaMutantBruton's tyrosine kinaseCell biologySignal transductionLeukemiaGeneTyrosine kinaseChronic Lymphocytic Leukemia ResearchImmune Cell Function and InteractionCAR-T cell therapy research