Secukinumab‐induced multiple lentigines in areas of resolved psoriatic plaques: A case report and literature review
Sanquan Zhang, Jingyao Liang, Xin Tian, Xin Zhou, Weiyu Liu, Xiaoyin Chen, Xibao Zhang
Abstract
Psoriasis is a systemic inflammatory disease commonly associated with postinflammatory hyper- and hypo-pigmentation. Psoriasis-related cytokines such as IL-17 and TNF can contribute to these pigmentation changes by regulating both the growth and pigment production of melanocytes. Here, we present the first reported the case of a patient with a 10-year history of severe psoriasis vulgaris, who developed multiple lentigines in areas of resolved psoriatic plaques during anti-IL-17A antibody secukinumab.
Topics & Concepts
SecukinumabMedicinePsoriasisDermatologyPsoriatic arthritisPlaque psoriasisPsoriasis: Treatment and Pathogenesismelanin and skin pigmentationAcne and Rosacea Treatments and Effects