Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan
Xiao Liu, Hao Fei, Hao Peng, Jingxue Zhang, Liqiang Wang, Si–Wei You, Ningli Wang, Zhaoyang Yang, Kwok‐Fai So, Xiaoguang Li
Abstract
The optic nerve, which belongs to the central nervous system (CNS), cannot regenerate when injured in adult mammals. 1 Up to now, no readily translatable measures are available for repairing a severely injured optic nerve. Herein we demonstrated that ciliary neurotrophic factor (CNTF)-chitosan enabled the reconstruction and functional recovery of the adult rat visual system, thus shedding light on the clinical potential for repairing the severely injured optic nerve.
Topics & Concepts
Regeneration (biology)Ciliary neurotrophic factorOptic nerveAnatomyMedicineBiologyPathologyCell biologyInternal medicineNeurotrophic factorsReceptorNerve injury and regenerationNeurogenesis and neuroplasticity mechanismsSupramolecular Self-Assembly in Materials